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Antidepressants | Clinical Depression

An antidepressant is a medication designed to treat or alleviate
the symptoms of clinical depression.

Some antidepressants, notably the tricyclics, are commonly used off-label in the treatment of neuropathic pain, whether or not the patient is depressed.

Smaller doses are generally used for this purpose, and they often take effect more quickly. Many antidepressants also are used for the treatment of anxiety disorders, and tricyclic antidepressants are used in the treatment of chronic pain disorders such as chronic functional abdominal pain (CFAP), myofascial pain syndrome, and post-herpetic neuralgia.

The main classes of antidepressants have similar efficacy, but the newer types are generally regarded to have a more benign side-effect profile and less risk of lethality if taken in overdose.

 

Like many psychiatric drugs, antidepressants were discovered by accident. The first antidepressants, imipramine, a tricyclic, and iproniazid, a monoamine oxidase inhibitor, were discovered in the 1950s. These drugs were found to have the side effect of improving the patients' mood. However, the newer SSRI antidepressants were early examples of rational drug design.

Clinical Depression

Clinical depression is state of sadness or melancholia that has advanced to the point of being disruptive to an individual's social functioning and/or activities of daily living.

The diagnosis may be applied when an individual meets a sufficient number of the symptomatic criteria for the depression spectrum as suggested in the DSM-IV-TR or ICD-9/10. It is important to note that an individual may suffer from what is termed a "clinical depression" without fully meeting the criteria for a specific diagnosis on the depression spectrum. Clinically, this is referred to as a "depressed mood". This state is typically psycho-social in nature, as opposed to organic (chemical). A strict clinical diagnosis of Depression, and/or its various corollaries, almost invariably maintains the presence of a biological component.

Although a mood characterized by sadness is often colloquially referred to as depression, clinical depression is something more than just a temporary state of sadness. Symptoms lasting two weeks or longer, and of a severity that begins to interfere with typical social functioning and/or activities of daily living, are considered to constitute clinical depression.

Clinical depression affects about 16% of the population on at least one occasion in their lives. The mean age of onset, from a number of studies, is in the late 20s. About twice as many females as males report or receive treatment for clinical depression, though this imbalance is shrinking over the course of recent history; this difference seems to completely disappear after the age of 50 - 55, when most females have passed the end of menopause. Clinical depression is currently the leading cause of disability in the US as well as other countries, and is expected to become the second leading cause of disability worldwide (after heart disease) by the year 2020, according to the World Health Organization.

More info: http://en.wikipedia.org/wiki/Clinical_depression

 

Antidepressants | Clinical Depression

 The information is derived from believed to be reliable government
sources and is not meant to be medical advice.
Clinical Depression needs to be treated by a qualified medical doctor.

 

Antidepressants | Clinical Depression